Lomitapide mesylate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$650	Check With Us
500mg	$1150	Check With Us
1g	$1725	Check With Us

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Cat #: V3505 CAS #: 202914-84-9 Purity ≥ 98%

Description: Lomitapide mesylate (AEGR733 mesylate; BMS201038; Juxtapid; Lojuxta), the mesylate salt of Lomitapide, is a microsomal triglyceride-transfer protein (MTP) inhibitor that has been approved by FDA as a lipid-lowering agent to treat homozygous familial hypercholesterolemia.

References: Sulsky R, et al. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5067-70.

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Physicochemical and Storage Information
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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	789.83
Molecular Formula	C40H41F6N3O5S
CAS No.	202914-84-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.2661 mL	6.3305 mL	12.6610 mL	25.3219 mL
5mM	0.2532 mL	1.2661 mL	2.5322 mL	5.0644 mL
10mM	0.1266 mL	0.6330 mL	1.2661 mL	2.5322 mL
20mM	0.0633 mL	0.3165 mL	0.6330 mL	1.2661 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.