LLY-507
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1450 | Check With Us |
| 500mg | $2150 | Check With Us |
| 1g | $3225 | Check With Us |
: Cat #: V24271 CAS #: 1793053-37-8 Purity ≥ 99%
Description: LLY-507 (LLY507) is a novel, potent, cell-permeable/active and selective inhibitor of protein-lysine methyltransferase SMYD2 (SET And MYND Domain Containing 2) with potential anticancer activity.
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| Molecular Weight (MW) | 574.76 |
|---|---|
| Molecular Formula | C36H42N6O |
| CAS No. | 1793053-37-8 |
| SMILES Code | O=C(C1=CC(C2=CC=CC=C2N3CCN(CCN4C=C(C)C5=C4C=CC=C5)CC3)=CC(C#N)=C1)NCCCN6CCCC6 |
| Synonyms | LLY507; LLY 507; LLY-507 |
| Protocol | In Vitro | LLY-507 (0-20 μM; 3-7 days) inhibits the proliferation of several ESCC, HCC, and breast cancer cell lines. LLY-507 (0.03-20 μM; 28 hours) inhibits SMYD2-mediated methylation of p53 Lys370 in U2OS cells, with an IC50 of 0.6 μM. LY-507 is able to potently inhibit the methylation of H4 peptide by SMYD2 enzyme with an IC50 of 31 nM. LLY-507 binds to the substrate channel of SMYD2 and supports the selectivity of its inhibition. LLY-507 is >100-fold selective for SMYD2 over 21 other methyltransferases including SMYD3. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7399 mL | 8.6993 mL | 17.3986 mL | 34.7971 mL |
| 5mM | 0.3480 mL | 1.7399 mL | 3.4797 mL | 6.9594 mL |
| 10mM | 0.1740 mL | 0.8699 mL | 1.7399 mL | 3.4797 mL |
| 20mM | 0.0870 mL | 0.4350 mL | 0.8699 mL | 1.7399 mL |
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.