Lirametostat (CPI-1205)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$1450	To Be Confirmed
250mg	$2350	To Be Confirmed
500mg	$3525	To Be Confirmed

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Cat #: V2607 CAS #: 1621862-70-1 Purity ≥ 98%

Description: Lirametostat (CPI-1205; CPI 1205, CPI1205) is an orally bioavailable and selective inhibitor of EZH2 (enhancer of zeste homologue 2, a histone lysine methyltransferase) with potential antitumor activity.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	518.57
Molecular Formula	C27H33F3N4O3
CAS No.	1621862-70-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (192.8 mM)r
	Water: <1 mg/mLr
	Ethanol: 100 mg/mL (192.8 mM)
SMILES Code	C[C@@H](N1C2=C(C(C(NCC3=C(C=C(NC3=O)C)OC)=O)=C1C)C=CC=C2)C4CCN(CC(F)(F)F)CC4
Synonyms	CPI1205; Lirametostat; CPI-1205; CPI 1205

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9284 mL	9.6419 mL	19.2838 mL	38.5676 mL
5mM	0.3857 mL	1.9284 mL	3.8568 mL	7.7135 mL
10mM	0.1928 mL	0.9642 mL	1.9284 mL	3.8568 mL
20mM	0.0964 mL	0.4821 mL	0.9642 mL	1.9284 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.