limaprost
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1950 | Check With Us |
| 200mg | $2925 | Check With Us |
| 500mg | $4935 | Check With Us |
: Cat #: V4638 CAS #: 74397-12-9 Purity ≥ 98%
Description: Limaprost (formerly ONO1206; OP1206; ONO-1206; OP-1206) is, an alprostadil (prostaglandin E1) analogue, is a novel and potent vasodilator that increases blood flow and inhibits platelet aggregation.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 380.52 |
|---|---|
| Molecular Formula | C22H36O5 |
| CAS No. | 74397-12-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(O)/C=C/CCCC[C@H]1C(C[C@@H](O)[C@@H]1/C=C/[C@@H](O)C[C@@H](C)CCCC)=O |
| Synonyms | ONO 1206; OP 1206; ONO 1206; ONO 1206; Limaprost; 17α,20-dimethyl-Δ2-PGE1; 17α,20-dimethyl-Δ2-Prostaglandin E1; |
| Protocol | In Vitro | Limaprost inhibits the IL-1-mediated induction of nerve growth factor (NGF) in a concentration-dependent manner with an IC50 value of 70.9 nM human IVD cells. |
|---|---|---|
| In Vivo | Limaprost (OP1206) given orally at more than 100 μg/kg relieves Argipressin-induced ST depression of rat electrocardiogram (ECG). Intra-coronary injection of Limaprost (OP1206; 1-100 ng/kg) in dogs results in a remarkable increase of coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption and redox potential. Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost (OP1206) at the same doses or doses less than those relieving Argipressin-induced ST depression of ECG. Resistance in both large and small vessels of dog coronary artery is decreased by intravenous injection of Limaprost (OP1206; 1-3 mg/kg). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6280 mL | 13.1399 mL | 26.2798 mL | 52.5597 mL |
| 5mM | 0.5256 mL | 2.6280 mL | 5.2560 mL | 10.5119 mL |
| 10mM | 0.2628 mL | 1.3140 mL | 2.6280 mL | 5.2560 mL |
| 20mM | 0.1314 mL | 0.6570 mL | 1.3140 mL | 2.6280 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
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V1
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Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.