Lidocaine hydrochloride

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100g	$550	Check With Us
200g	$800	Check With Us
500mg	$1350	Check With Us

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Cat #: V29472 CAS #: 73-78-9 Purity ≥ 99%

Description: Lidocaine hydrochloride monohydrate (also known as Alphacaine; Lignocaine) is a potent and selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Lidocaine is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. Originally developed as a local anesthetic, it has properties as a class IB antiarrhythmic, a long-acting membrane stabilizing agent used against ventricular arrhythmia. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacine or prilocaine.

References: [1]. Cummins TR, et al. Setting up for the block: the mechanism underlying lidocaine's use-dependent inhibition of sodium channels. J Physiol. 2007 Jul 1;582(Pt 1):11.

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Molecular Weight (MW)	270.80
Molecular Formula	C₁₄H₂₃ClN₂O
CAS No.	73-78-9
SMILES Code	O=C(NC1=C(C)C=CC=C1C)CN(CC)CC.[H]Cl
Synonyms	Lignocaine hydrochloride

Protocol	In Vitro	Lidocaine hydrochloride (Lignocaine hydrochloride) (10 nM; 48 hours) decreases significantly cell proliferation. Lidocaine hydrochloride (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10 nM and treatment time 48 hours. Lidocaine hydrochloride (10 nM; 48 hours) increases significantly the apoptotic cell rate. Lidocaine hydrochloride (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly.
Protocol	In Vivo	Lidocaine hydrochloride (Lignocaine hydrochloride) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.6928 mL	18.4638 mL	36.9276 mL	73.8552 mL
5mM	0.7386 mL	3.6928 mL	7.3855 mL	14.7710 mL
10mM	0.3693 mL	1.8464 mL	3.6928 mL	7.3855 mL
20mM	0.1846 mL	0.9232 mL	1.8464 mL	3.6928 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.