Lexithromycin

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$1350	Check With Us
200mg	$2025	Check With Us
500mg	$3410	Check With Us

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Cat #: V16746 CAS #: 53066-26-5 Purity ≥ 99%

Description: Lexithromycin (Erythromycin A 9-methoxime; Wy 48314) is a potent and semi-synthetic antibiotic derived from erythromycin A with antibacterial activity.

References: Hunt E, et al. Erythromycin A 11,12-methylene acetal. J Antibiot (Tokyo). 1988 Nov;41(11):1644-8.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	762.97
Molecular Formula	C38H70N2O13
CAS No.	53066-26-5
SMILES Code	CC[C@H]1OC([C@@H]([C@H]([C@@H]([C@H]([C@](O)(C[C@H](/C([C@@H]([C@H]([C@@]1(O)C)O)C)=NOC)C)C)O[C@@H]2O[C@@H](C[C@H](N(C)C)[C@H]2O)C)C)O[C@H]3C[C@@](OC)([C@H]([C@@H](O3)C)O)C)C)=O
Synonyms	Lexithromycin; Wy 48314; Wy48314; Wy-48314;

Protocol	In Vitro	Lexithromycin is an erythromycin A derivative, with antibacterial activity. Lexithromycin shows minimal inhibitory concentration (MIC) of 0.06 μg/mL against S. pyogenes CN10A and Streptococcus sp. 64/848C, 0.25 μg/mL against Staphylococcus aureus Oxford, 0.5 μg/mL against S. aureus Russell and S. aureus T2, 4 μg/mL against S. pyogenes CN10A and Haemophilus influenzae Wy 21.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.3107 mL	6.5533 mL	13.1067 mL	26.2134 mL
5mM	0.2621 mL	1.3107 mL	2.6213 mL	5.2427 mL
10mM	0.1311 mL	0.6553 mL	1.3107 mL	2.6213 mL
20mM	0.0655 mL	0.3277 mL	0.6553 mL	1.3107 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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