Levothyroxine Sodium
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 10g | $600 | Check With Us |
| 25g | $1100 | Check With Us |
| 50g | $1650 | Check With Us |
: Cat #: V22762 CAS #: 55-03-8 Purity ≥ 99%
Description: Levothyroxine Sodium (L-T4 sodium, LT4 sodium, LT4 sodium, L-Thyroxine sodium), a major thyroid hormones involved in the maintenance of metabolic homeostasis, is an endogenous agonist of Thyroid hormone receptor alpha and beta.
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| Molecular Weight (MW) | 798.85 |
|---|---|
| Molecular Formula | C15H10I4NNaO4 |
| CAS No. | 55-03-8 |
| Synonyms | Levothyroxine sodium; T4 sodium; L-Thyroxine sodium |
| Protocol | In Vitro | Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.2518 mL | 6.2590 mL | 12.5180 mL | 25.0360 mL |
| 5mM | 0.2504 mL | 1.2518 mL | 2.5036 mL | 5.0072 mL |
| 10mM | 0.1252 mL | 0.6259 mL | 1.2518 mL | 2.5036 mL |
| 20mM | 0.0626 mL | 0.3129 mL | 0.6259 mL | 1.2518 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.