Levosimendan
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $645 | Check With Us |
| 2g | $900 | Check With Us |
| 5g | $1520 | Check With Us |
: Cat #: V24041 CAS #: 141505-33-1 Purity ≥ 99%
Description: Levosimendan (trade name Simdax) is a novel and potent calcium sensitizer that has been used in the management of acutely decompensated congestive heart failure.
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| Molecular Weight (MW) | 280.28 |
|---|---|
| Molecular Formula | C14H12N6O |
| CAS No. | 141505-33-1 |
| SMILES Code | CC1CC(=O)NN=C1C2=CC=C(C=C2)NN=C(C#N)C#N |
| Synonyms | OR 1259; OR-1259; OR-1855; Simadax; simendan; Levosimendan; Simdax; Levosimendanum; Levosimedan; (-)-OR-1259; dextrosimendan; Levosimendan; |
| Protocol | In Vitro | Levosimendan (OR1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. Levosimendan (OR1259) is an inodilator indicated for the short-term treatment of acutely decompensated severe chronic heart failure, and in situations where conventional therapy is not considered adequate. Levosimendan (OR1259) has shown preliminary positive effects in a range of conditions requiring inotropic support, including right ventricular failure, cardiogenic shock, septic shock, and Takotsubo cardiomyopathy. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5679 mL | 17.8393 mL | 35.6786 mL | 71.3572 mL |
| 5mM | 0.7136 mL | 3.5679 mL | 7.1357 mL | 14.2714 mL |
| 10mM | 0.3568 mL | 1.7839 mL | 3.5679 mL | 7.1357 mL |
| 20mM | 0.1784 mL | 0.8920 mL | 1.7839 mL | 3.5679 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.