Letrozole (CGS 20267)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $250 | In Stock |
| 10g | $400 | In Stock |
| 20g | $600 | In Stock |
: Cat #: V1798 CAS #: 112809-51-5 Purity ≥ 98%
Description: Letrozole (formerly known as CGS-20267; trade name: Femara; Letoval) is a third generation, nonsteroidal inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays and has anticancer activities.
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- Related Biological Data
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| Molecular Weight (MW) | 285.3 |
|---|---|
| Molecular Formula | C17H11N5 |
| CAS No. | 112809-51-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 57 mg/mL (199.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 0.5% CMC: 10 mg/mL |
| Synonyms | Abbreviation; CGS 20267; CGS20267; CGS-20267; LTZ; Trade name: Femara; Letoval; Chemical Name: 4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile SMILES Code: N#CC1=CC=C(C(C2=CC=C(C#N)C=C2)N3N=CN=C3)C=C1 Exact Mass: 285.10145 |
| Protocol | In Vitro | Letrozole (0.1-100 nM; 24-96 h) significantly inhibits growth of the MCF-7 epithelial breast cancer cells in a dose- and time-dependent manner |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5051 mL | 17.5254 mL | 35.0508 mL | 70.1016 mL |
| 5mM | 0.7010 mL | 3.5051 mL | 7.0102 mL | 14.0203 mL |
| 10mM | 0.3505 mL | 1.7525 mL | 3.5051 mL | 7.0102 mL |
| 20mM | 0.1753 mL | 0.8763 mL | 1.7525 mL | 3.5051 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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C1
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.