LDN-211904 oxalate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1mg	$280	To Be Confirmed

: sales@invivochem.com sales@invivochem.cn

Cat #: V46239 CAS #: 1198408-78-4 Purity ≥ 99%

Description: LDN-211904 oxalate (compound 32) is a potent and specific EphB3 inhibitor (antagonist) with IC50 of 0.079 µM. LDN-211904 oxalate displays good metabolic stability in mouse liver microsomes. LDN-211904 oxalate in combination with cetuximab effectively inhibits STAT3-activated CSC stemness and cetuximab resistance in CRC.

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Molecular Weight (MW)	444.868243932724
Molecular Formula	C21H21CLN4O5
CAS No.	1198408-78-4
Storage	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2479 mL	11.2393 mL	22.4786 mL	44.9571 mL
5mM	0.4496 mL	2.2479 mL	4.4957 mL	8.9914 mL
10mM	0.2248 mL	1.1239 mL	2.2479 mL	4.4957 mL
20mM	0.1124 mL	0.5620 mL	1.1239 mL	2.2479 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.