LDC4297
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1650 | Check With Us |
| 500mg | $2680 | Check With Us |
| 1g | $4000 | Check With Us |
: Cat #: V2731 CAS #: 1453834-21-3 Purity ≥ 98%
Description: LDC4297 is a novel and potent CDK7 (Cyclin-dependent protein kinase 7) inhibitor with IC50 of 0.13±0.06 nM for CDK7 and IC50s between 10 nM and 10,000 nM for all other analyzed CDKs.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 432.52 |
|---|---|
| Molecular Formula | C23H28N8O |
| CAS No. | 1453834-21-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 86 mg/mL (198.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 86 mg/mL (198.8 mM) | |
| Synonyms | LDC044297; LCD-044297; LCD 044297; LDC4297; LDC-4297; LDC 4297 |
| Protocol | In Vitro | LDC4297 (20 μM; 12-96 h) shows anti-HCMV activity through a multifaceted mode of action that involves an interference with virus-induced Rb phosphorylation. |
|---|---|---|
| In Vivo | LDC4297 (100 mg/kg; p.o. once) shows promising pharmacokinetic analyses. | |
| Animal model | CD1 mice | |
| Dosages | 100 mg/kg | |
| Administration | Oral gavage; 100 mg/kg once |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3120 mL | 11.5602 mL | 23.1203 mL | 46.2406 mL |
| 5mM | 0.4624 mL | 2.3120 mL | 4.6241 mL | 9.2481 mL |
| 10mM | 0.2312 mL | 1.1560 mL | 2.3120 mL | 4.6241 mL |
| 20mM | 0.1156 mL | 0.5780 mL | 1.1560 mL | 2.3120 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.