Lazabemide
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $420 | Check With Us |
| 1g | $630 | Check With Us |
| 5g | $1890 | Check With Us |
: Cat #: V4155 CAS #: 103878-84-8 Purity ≥ 98%
Description: Lazabemide (also known as Ro 19-6327; proposed trade names Pakio, Tempium) is novel, potent, selective, reversible monoamine oxidase B (MAO-B) inhibitor with IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively.
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- Related Biological Data
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| Molecular Weight (MW) | 199.64 |
|---|---|
| Molecular Formula | C₈H₁₀ClN₃O |
| CAS No. | 103878-84-8 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| SMILES Code | ClC1=CC=C(C(NCCN)=O)N=C1 |
| Synonyms | Ro 19-6327; Ro-19-6327; Ro 19 6327 |
| Protocol | In Vivo | Lazabemide (3 mg/kg) attenuates ichemia reperfusion-induced hydroxyl radical generation and pretreatment with Lazabemide showed decreased DOPAC levels in comparison with those of their respective vehicle-treated control groups |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 5.0090 mL | 25.0451 mL | 50.0902 mL | 100.1803 mL |
| 5mM | 1.0018 mL | 5.0090 mL | 10.0180 mL | 20.0361 mL |
| 10mM | 0.5009 mL | 2.5045 mL | 5.0090 mL | 10.0180 mL |
| 20mM | 0.2505 mL | 1.2523 mL | 2.5045 mL | 5.0090 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.