This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | 3-6 Days |
| 10mg | $145 | 3-6 Days |
| 25mg | $235 | 3-6 Days |
| 50mg | $335 | 3-6 Days |
| 100mg | $445 | 3-6 Days |
| 250mg | $680 | 3-6 Days |
| 500mg | $1000 | 3-6 Days |
: Cat #: V17003 CAS #: 439239-92-6 Purity ≥ 98%
Description: Lasmiditan succinate (COL-144, LY-573144) is a novel and selective 5-HT(1F) receptor agonist with Ki of 2.1 nM versus Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively. For the understanding of migraine pathophysiology, it is very important to note that a selective 5-HT(1F) receptor agonist like lasmiditan is effective in the acute treatment of migraine. Thus, migraine can be treated with a drug that has no vasoconstrictor ability. While lasmiditan most likely is effective in the treatment of migraine attacks it had, unfortunately, a high incidence of CNS related AEs in the oral RCT. If confirmed in larger studies in phase III, this might adversely limit the use of this highly specific non-vascular acute treatment of migraine. Larger studies including the parameters of patients' preferences are necessary to accurately position this new treatment principle in relation to the triptans.
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| Molecular Weight (MW) | 872.82 |
|---|---|
| Molecular Formula | C42H42F6N6O8 |
| CAS No. | 439239-92-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10mM |
| Water: N/A | |
| Ethanol: N/A | |
| SMILES Code | O=C(NC1=NC(C(C2CCN(C)CC2)=O)=CC=C1)C3=C(F)C=C(F)C=C3F.O=C(NC4=NC(C(C5CCN(C)CC5)=O)=CC=C4)C6=C(F)C=C(F)C=C6F.O=C(O)CCC(O)=O |
| Synonyms | LY573144 succinate; LY-573144; LY 573144; COL-144; COL144; COL 144 succinate |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.1457 mL | 5.7286 mL | 11.4571 mL | 22.9142 mL |
| 5mM | 0.2291 mL | 1.1457 mL | 2.2914 mL | 4.5828 mL |
| 10mM | 0.1146 mL | 0.5729 mL | 1.1457 mL | 2.2914 mL |
| 20mM | 0.0573 mL | 0.2864 mL | 0.5729 mL | 1.1457 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.