LASMIDITAN HCl (COL144 HCl, LY573144 HCl)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5mg	$90	3-6 Days
10mg	$135	3-6 Days
25mg	$235	3-6 Days
50mg	$350	3-6 Days
100mg	$550	3-6 Days
250mg	$999	3-6 Days
500mg	$1430	3-6 Days

: [email protected] [email protected]

Cat #: V3981 CAS #: 613677-28-4 Purity ≥ 98%

Description: Lasmiditan HCl (formerly COL-144 HCl, LY-573144 HCl) is a novel and selective 5-HT(1F) receptor agonist with Ki of 2.1 nM versus Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively. For the understanding of migraine pathophysiology, it is very important to note that a selective 5-HT(1F) receptor agonist like lasmiditan is effective in the acute treatment of migraine. Thus, migraine can be treated with a drug that has no vasoconstrictor ability. While lasmiditan most likely is effective in the treatment of migraine attacks it had, unfortunately, a high incidence of CNS related AEs in the oral RCT. If confirmed in larger studies in phase III, this might adversely limit the use of this highly specific non-vascular acute treatment of migraine. Larger studies including the parameters of patients' preferences are necessary to accurately position this new treatment principle in relation to the triptans.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	413.82
Molecular Formula	C19H18F3N3O2-HCl
CAS No.	613677-28-4
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: >10mM
	Water: N/A
	Ethanol: N/A
SMILES Code	O=C(NC1=NC(C(C2CCN(C)CC2)=O)=CC=C1)C3=C(F)C=C(F)C=C3F.[H]Cl
Synonyms	LY573144 HCl; LY-573144; LY 573144; COL-144; COL144 HCl; COL 144

Related Biological Data

Proportion of migraine patients with headache relief (a decrease of headache from moderate or severe to none or mild) (HR) at 2 h after intravenous lasmiditan (PBO placebo). J Headache Pain. 2012 Jun;13(4):271-5.

Proportion of migraine patients with HR at 2 h after oral lasmiditan 50–400 mg (PBOplacebo). J Headache Pain. 2012 Jun;13(4):271-5.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4165 mL	12.0825 mL	24.1651 mL	48.3302 mL
5mM	0.4833 mL	2.4165 mL	4.8330 mL	9.6660 mL
10mM	0.2417 mL	1.2083 mL	2.4165 mL	4.8330 mL
20mM	0.1208 mL	0.6041 mL	1.2083 mL	2.4165 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.