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Laduviglusib (CHIR-99021; dihydrochloride)

This product is for research use only, not for human use. We do not sell to patients.

Laduviglusib (CHIR-99021; dihydrochloride)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$783-6 Days
10mg$1203-6 Days
25mg$1993-6 Days
50mg$2893-6 Days
100mg$4503-6 Days
250mg$7793-6 Days
500mg$10703-6 Days
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Cat #: V2247 CAS #: 2109414-84-6 Purity ≥ 98%

Description: Laduviglusib (CHIR-99021; CHIR99021) 2HCl, the dihydrochloride of CHIR-99021, is a potent and selective inhibitor of glycogen synthase kinase 3α/β (GSK-3α/β) with IC50s of 10 nM and 6.7 nM, respectively. Reference: PLoS One. 2013;8(3):e58501.

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CAS No.2109414-84-6
ProtocolAnimal modelFemale db/db mice or male ZDF rats with type 2 diabetes
FormulationFormulated as solutions in 20 mM citrate-buffered 15% Captisol or as fine suspensions in 0.5% carboxymethylcellulose.
Dosages48 mg/kg
AdministrationOral gavage
These protocols are for reference only. InvivoChem does not independently validate these methods.
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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V1
 
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Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.