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|---|---|
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: Cat #: V2591 CAS #: 159182-43-1 Purity ≥ 98%
Description: L-755,507 is identified as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM, it displayed > 1000-fold selective over β1- and β2-adrenoceptors (EC50 values are 0.43, 580 and > 10000 nM for activation of cloned human β3-, β1- and β2-adrenoceptors respectively). It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
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| Molecular Weight (MW) | 584.73 |
|---|---|
| Molecular Formula | C30H40N4O6S |
| CAS No. | 159182-43-1 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (171.0 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Synonyms | L-755507; L 755507; L755507 |
| Protocol | In Vitro | In vitro activity: L-755,507 displays an excellent activity profile as an extremely potent human β3 adrenergic receptor agonist (β3 EC50 0.43 nM), with >440-fold selectivity over β1 and β2 binding. L755507 causes a robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors(pEC50 values of 12.3). In a recent study employing a high-throughput screen to identify chemicals capable of modulating HR-mediated genome editing, L-755507 is identified that could enhance HR repair by up to ninefold. Kinase Assay: L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types. |
|---|---|---|
| In Vivo | Acute exposure of rhesus monkeys to L-755,507 elicits lipolysis and metabolic rate elevation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose tissue. | |
| Animal model | Male lean rhesus monkeys |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7102 mL | 8.5510 mL | 17.1019 mL | 34.2038 mL |
| 5mM | 0.3420 mL | 1.7102 mL | 3.4204 mL | 6.8408 mL |
| 10mM | 0.1710 mL | 0.8551 mL | 1.7102 mL | 3.4204 mL |
| 20mM | 0.0855 mL | 0.4275 mL | 0.8551 mL | 1.7102 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.