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L-685,458

This product is for research use only, not for human use. We do not sell to patients.

L-685,458
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$2550Check With Us
200mg$3825Check With Us
500mg$6455Check With Us
email: [email protected]        [email protected]

Cat #: V0719 CAS #: 292632-98-5 Purity ≥ 98%

Description: L-685,458 (also called L685458; L-685458) is a selective inhibitor of Aß PP γ-secretase with potential anti-AD and anticancer activity.

References: Shearman, M.S., Beher, D., Clarke, E.E., Lewis, H.D., Harrison, T., Hunt, P.,

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Molecular Weight (MW)672.85
Molecular FormulaC39H52N4O6
CAS No.292632-98-5
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 100 mg/mL (148.6 mM)r
Water: <1 mg/mLr
Ethanol: 6 mg/mL warmed (8.9 mM)
SMILES CodeO=C(OC(C)(C)C)N[C@H]([C@H](O)C[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CC=CC=C2)C(N)=O)=O)=O)CC3=CC=CC=C3
SynonymsL685458; L685,458; L-685,458; L 685,458; L-685458; L 685458;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.4862 mL7.4311 mL14.8622 mL29.7243 mL
5mM0.2972 mL1.4862 mL2.9724 mL5.9449 mL
10mM0.1486 mL0.7431 mL1.4862 mL2.9724 mL
20mM0.0743 mL0.3716 mL0.7431 mL1.4862 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.