KRIBB11
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $799 | Check With Us |
| 500mg | $1288 | Check With Us |
| 1g | $1932 | Check With Us |
: Cat #: V2713 CAS #: 342639-96-7 Purity ≥ 98%
Description: KRIBB11, a novel and potent inhibitor of Heat shock factor 1 (HSF1), abolishes the heat shock-induced luciferase activity with an IC50 of 1.2 μM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 284.27 |
|---|---|
| Molecular Formula | C13H12N6O2 |
| CAS No. | 342639-96-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 3 mg/mL (10.55 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Synonyms | KRIBB11; KRIBB-11; KRIBB 11 |
| Protocol | In Vitro | KRIBB11 blocks the induction of HSF27 downstream target proteins such as HSP70 and HSP1. KRIBB11 induces growth arrest and apoptosis in HCT-116 cells. KRIBB11 inhibits HSF1-dependent p-TEFb (positive transcriptional elongation factor b) recruitment to the hsp70 promoter |
|---|---|---|
| In Vivo | KRIBB11 (50 mg/kg, intraperitoneal injection) inhibited tumor growth in nude mice in 47.4% without weight loss |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5178 mL | 17.5889 mL | 35.1778 mL | 70.3556 mL |
| 5mM | 0.7036 mL | 3.5178 mL | 7.0356 mL | 14.0711 mL |
| 10mM | 0.3518 mL | 1.7589 mL | 3.5178 mL | 7.0356 mL |
| 20mM | 0.1759 mL | 0.8794 mL | 1.7589 mL | 3.5178 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.