Kobe0065
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $410 | Check With Us |
| 500mg | $680 | Check With Us |
| 1g | $1020 | Check With Us |
: Cat #: V2563 CAS #: 436133-68-5 Purity ≥ 98%
Description: Kobe0065 (Kobe 0065) is novel and potent inhibitor of the H-Ras-cRaf1 interaction which exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.
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| Molecular Weight (MW) | 449.79 |
|---|---|
| Molecular Formula | C15H11ClF3N5O4S |
| CAS No. | 436133-68-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 89 mg/mL (197.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 13 mg/mL (28.9 mM) | |
| Synonyms | Kobe-0065; Kobe 0065; Kobe0065 |
| Protocol | In Vitro | Kobe0065-family compounds bind to Ras•GTP and exhibit antiproliferative activity toward cancer cells carrying the activated ras oncogenes. The compounds efficiently inhibit the interaction of Ras•GTP with their multiple effectors including Raf, PI3K, and RalGDS and a regulator/effector Sos and show rather broad binding specificity toward various Ras family small GTPases, which may account for their higher potency at the cellular level compared with that of the in vitro binding inhibition |
|---|---|---|
| In Vivo | Kobe0065 and Kobe2602 exhibit antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-ras(G12V) gene by oral administration |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2233 mL | 11.1163 mL | 22.2326 mL | 44.4652 mL |
| 5mM | 0.4447 mL | 2.2233 mL | 4.4465 mL | 8.8930 mL |
| 10mM | 0.2223 mL | 1.1116 mL | 2.2233 mL | 4.4465 mL |
| 20mM | 0.1112 mL | 0.5558 mL | 1.1116 mL | 2.2233 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.