KN-62
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In Stock |
| 10mg | $140 | In Stock |
| 25mg | $210 | In Stock |
| 50mg | $330 | In Stock |
| 100mg | $550 | In Stock |
| 250mg | $950 | In Stock |
| 500mg | $1550 | In Stock |
: Cat #: V1298 CAS #: 127191-97-3 Purity ≥ 98%
Description: KN-62 (KN62; KN 62) is a potent, selective, cell-permeable and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 721.84 |
|---|---|
| Molecular Formula | C38H35N5O6S2 |
| CAS No. | 127191-97-3 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (138.5 mM)rr |
| Water:<1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| Synonyms | KN62; KN-62; KN 62. |
| Protocol | In Vitro | KN-62 potently antagonizes ATP-stimulated Ba2+ influx into fura-2 loaded human lymphocytes with an IC50 of 12.7 nM and complete inhibition of the flux at a concentration of 500 nM |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.3853 mL | 6.9267 mL | 13.8535 mL | 27.7070 mL |
| 5mM | 0.2771 mL | 1.3853 mL | 2.7707 mL | 5.5414 mL |
| 10mM | 0.1385 mL | 0.6927 mL | 1.3853 mL | 2.7707 mL |
| 20mM | 0.0693 mL | 0.3463 mL | 0.6927 mL | 1.3853 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.