KHS101 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $900 | In Stock |
| 500mg | $1450 | In Stock |
| 1g | $2175 | In Stock |
: Cat #: V4030 CAS #: 1784282-12-7 Purity ≥ 98%
Description: KHS101 HCl, the hydrochloride salt of KHS-101, is a novel, selective and synthetic small-molecule inhibitor of transforming acidic coiled-coil protein 3 (TACC3) with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 375.91 |
|---|---|
| Molecular Formula | C18H22ClN5S |
| CAS No. | 1784282-12-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 150mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1.[H]Cl |
| Synonyms | KHS-101 HCl; KHS101 hydrochloride; KHS 101 HCl; KHS101 HCl; KHS-101 hydrochloride; KHS 101 hydrochloride |
| Protocol | In Vitro | KHS101 increases neuronal differentiation of adherently cultured rat NPCs in a dose-dependent fashion (EC50 ~1 μM). KHS101 (1.5–5 μM) induces neuron formation (40-60% TuJ1+ cells) under neurosphere-forming conditions in secondary neurospheres derived from both the hippocampus and the subventricular zone (SVZ) of adult rats. Moreover, hippocampal NPCs treated with KHS101 and cultured adherently on microelectrode arrays for 12 d exhibit neuronal morphologies as well as spontaneous spiking activity, hence indicating the presence of functional, maturing neurons |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6602 mL | 13.3011 mL | 26.6021 mL | 53.2042 mL |
| 5mM | 0.5320 mL | 2.6602 mL | 5.3204 mL | 10.6408 mL |
| 10mM | 0.2660 mL | 1.3301 mL | 2.6602 mL | 5.3204 mL |
| 20mM | 0.1330 mL | 0.6651 mL | 1.3301 mL | 2.6602 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.