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| Size | Price | Stock |
|---|---|---|
| 5mg | $260 | 3-6 Days |
| 10mg | $430 | 3-6 Days |
| 25mg | $680 | 3-6 Days |
| 50mg | $1050 | 3-6 Days |
: Cat #: V23219 CAS #: 1131456-28-4 Purity ≥ 99%
Description: KGP94 is a novel, potent, reversible, time-dependent and competitive inhibitor of human cysteine protease Cathepsin L inhibitor(CTSL). It inhibits the activity of cathepsin L toward human type I collagen. KGP94 significantly impedes both migration and invasion of MDA-MB-231 human breast cancer cells. Molecular modeling places the thiocarbonyl of KGP94 in proximity to the active site Cys25. Significant growth retardation of C3H mouse mammary carcinomas is achieved with KGP94 treatment [1,2]. KGP94 treatment led to marked attenuation of tumor cell invasion and migration under both normal and aberrant microenvironmental conditions suggesting that it may have significant utility as an anti-metastatic agent. [3]
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| Molecular Weight (MW) | 350.233580589294 |
|---|---|
| Molecular Formula | C14H12BRN3OS |
| CAS No. | 1131456-28-4 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8552 mL | 14.2762 mL | 28.5524 mL | 57.1047 mL |
| 5mM | 0.5710 mL | 2.8552 mL | 5.7105 mL | 11.4209 mL |
| 10mM | 0.2855 mL | 1.4276 mL | 2.8552 mL | 5.7105 mL |
| 20mM | 0.1428 mL | 0.7138 mL | 1.4276 mL | 2.8552 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.