Ketoconazole

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10g	$650	Check With Us
25g	$1200	Check With Us
50g	$1800	Check With Us

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Cat #: V0804 CAS #: 65277-42-1; Purity ≥ 99%

Description: Ketoconazole (Ketoconazol; Fungoral, Nizoral, Kuric, Xolegel, Ketoderm; Extina; R-41400; R 41400), a CYP3A4 and 24A1 inhibitor and antifungal agent, is a potent and synthetic imidazole-based antifungal drug used primarily to treat fungal infections.

References: Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51(2):165-75.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	531.43
Molecular Formula	C26H28Cl2N4O4
CAS No.	65277-42-1;
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 7 mg/mL (13.2 mM)r
	Water: <1 mg/mLr
	Ethanol: 5 mg/mL (9.4 mM)
Solubility In Vivo	30% propylene glycol, 5% Tween 80, 65% D5W: 30mg/mL
SMILES Code	CC(N1CCN(C2=CC=C(OC[C@@H]3O[C@@](CN4C=CN=C4)(C5=CC=C(Cl)C=C5Cl)OC3)C=C2)CC1)=O
Synonyms	Ketoconazole; Nizoral, Kuric, Fungoral, Ketoderm; Xolegel, Extina

Protocol	In Vitro	Ketoconazole (R-41400), an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosterone levels, in men being treated for chronic mycotic infections.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8817 mL	9.4086 mL	18.8172 mL	37.6343 mL
5mM	0.3763 mL	1.8817 mL	3.7634 mL	7.5269 mL
10mM	0.1882 mL	0.9409 mL	1.8817 mL	3.7634 mL
20mM	0.0941 mL	0.4704 mL	0.9409 mL	1.8817 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.