KEA1-97
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1500 | Check With Us |
| 1g | $2400 | Check With Us |
| 5g | $6075 | Check With Us |
: Cat #: V23175 CAS #: 2138882-71-8 Purity ≥ 99%
Description: KEA1-97 is a novel and potent hioredoxin-caspase 3 interaction disruptor.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 335.16 |
|---|---|
| Molecular Formula | C15H9Cl2FN4 |
| CAS No. | 2138882-71-8 |
| SMILES Code | ClC1=NC(Cl)=NC(NC2=CC=C(C3=CC=C(F)C=C3)C=C2)=N1 |
| Synonyms | KEA1-97; KEA1 97; KEA197; |
| Protocol | In Vitro | KEA1-97 (231MFP cells) resistants to survival and proliferation impairments. KEA1-97 (10 μM; 0~12 hours; 231MFP cells) activates caspase 3/7 and induces apoptotic cell death. KEA1-97 (10 μM; 48 hours; 231MFP cells) impaires 231MFP serum-free cell proliferation. KEA1-97 (100 μM; 231MFP cells) impaires thioredoxin pulldown of caspase 3. |
|---|---|---|
| In Vivo | KEA1-97 (5 mg/kg; i.p.; 50 days) attenuates tumor xenograft growth. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9836 mL | 14.9182 mL | 29.8365 mL | 59.6730 mL |
| 5mM | 0.5967 mL | 2.9836 mL | 5.9673 mL | 11.9346 mL |
| 10mM | 0.2984 mL | 1.4918 mL | 2.9836 mL | 5.9673 mL |
| 20mM | 0.1492 mL | 0.7459 mL | 1.4918 mL | 2.9836 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.