KC7F2
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $750 | Check With Us |
| 1g | $1250 | Check With Us |
| 5g | $3160 | Check With Us |
: Cat #: V0299 CAS #: 927822-86-4 Purity ≥ 98%
Description: KC7F2 is a novel and potent HIF-1 (hypoxia inducible factor-1) pathway inhibitor with potential anticancer activity.
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| Molecular Weight (MW) | 570.38 |
|---|---|
| Molecular Formula | C16H16Cl4N2O4S4 |
| CAS No. | 927822-86-4 |
| SMILES Code | ClC1=C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)C=C(Cl)C=C1 |
| Synonyms | KC7F2; KC 7F2; KC-7F2; |
| Protocol | In Vitro | KC7F2 represses the phosphorylation of eukaryotic initiation factor 4E binding protein 1 (4EBP1). KC7F2 inhibits HIF-1α protein synthesis but not its mRNA transcription. KC7F2 does not affect the rate of HIF-1α protein degradation. KC7F2 (0-80 μM; 6 hours) specifically reduces the protein levels of HIF-1α in a dose-dependent manner under hypoxic conditions; strongly decrease in HIF-1α levels at concentrations above 20 μM. KC7F2 (15–25 μM; 0-72 hours) exhibits a clear dose-response cytotoxicity with an IC50 value of approximately 15–25 μM depending on the cell lines, and this effect is more severe under hypoxic conditions. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7532 mL | 8.7661 mL | 17.5322 mL | 35.0643 mL |
| 5mM | 0.3506 mL | 1.7532 mL | 3.5064 mL | 7.0129 mL |
| 10mM | 0.1753 mL | 0.8766 mL | 1.7532 mL | 3.5064 mL |
| 20mM | 0.0877 mL | 0.4383 mL | 0.8766 mL | 1.7532 mL |
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.