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Kartogenin (KGN)

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Kartogenin (KGN)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$619Check With Us
500mg$950Check With Us
1g$1425Check With Us
email: [email protected]        [email protected]

Cat #: V1368 CAS #: 4727-31-5 Purity ≥ 98%

Description: Kartogenin (abbreviated as KGN) is a small heterocyclic compound acting as an activator/inducer of the smad4/smad5 pathway.

References: Johnson K, et, al. A stem cell-based approach to cartilage repair. Science. 2012 May 11;336(6082):717-21.

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Molecular Weight (MW)317.34
Molecular FormulaC20H15NO3
CAS No.4727-31-5
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 63 mg/mL (198.5 mM)r
Water: <1 mg/mLr
Ethanol: 18 mg/mL (56.7 mM)
Solubility In VivoO=C(O)C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O
SynonymsKGN
ProtocolIn VitroKartogenin (100 nM; 72 h) induces chondrocyte nodule formation in primary hMSCs. Kartogenin (10 nM-10 μM; 72 h) increases chondrocyte-specific gene expression in hMSCs. Kartogenin (0.12-10 μM; 48 h) inhibits nitric oxide (NO) and glycosaminoglycan (GAG) release induced by cytokines in primary bovine articular chondrocytes
In VivoKartogenin (10 μM in 4μL of saline; i.a. on days 7 and 21) promotes cartilag erepair in collagenase VII-induced OA models in mice
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.1512 mL15.7560 mL31.5119 mL63.0239 mL
5mM0.6302 mL3.1512 mL6.3024 mL12.6048 mL
10mM0.3151 mL1.5756 mL3.1512 mL6.3024 mL
20mM0.1576 mL0.7878 mL1.5756 mL3.1512 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.