K6PC-5
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $750 | To Be Confirmed |
| 250mg | $1350 | To Be Confirmed |
| 500mg | $2025 | To Be Confirmed |
: Cat #: V23101 CAS #: 756875-51-1 Purity ≥ 99%
Description: K6PC-5 is a novel and potent sphingosine kinase 1 (SphK1) activator with potential usefulness for skin diseases.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 343.50 |
|---|---|
| Molecular Formula | C19H37NO4 |
| CAS No. | 756875-51-1 |
| SMILES Code | CCCCCCCC(C(CCCCCC)C(NC(CO)CO)=O)=O |
| Synonyms | K6PC-5; K6PC 5; K6PC5 |
| Protocol | In Vitro | K6PC-5 (1-10 μM; 24 h) increases the involucrin and loricrin levels in a dose-dependent manner in normal human epidermal keratinocytes (NHEKs). K6PC-5 promotes differentiation and proliferation of keratinocytes via intracellular Ca2+ signaling. In addition, K6PC-5 stimulates the phosphorylation of p42/44 extracellular signal-regulated kinase and c-Jun N-terminal kinase. |
|---|---|---|
| In Vivo | In intrinsically aged hairless mice (56 weeks old), 1% K6PC-5 is applied topically for 2 weeks. This K6PC-5 treatment significantly increases both the number of dermal fibroblasts and collagen production. As a consequence, dermal thickness also increased significantly. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9112 mL | 14.5560 mL | 29.1121 mL | 58.2242 mL |
| 5mM | 0.5822 mL | 2.9112 mL | 5.8224 mL | 11.6448 mL |
| 10mM | 0.2911 mL | 1.4556 mL | 2.9112 mL | 5.8224 mL |
| 20mM | 0.1456 mL | 0.7278 mL | 1.4556 mL | 2.9112 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.