K145 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1020 | Check With Us |
| 500mg | $1550 | Check With Us |
| 1g | $2325 | Check With Us |
: Cat #: V5052 CAS #: 1449240-68-9 Purity ≥ 98%
Description: K145 is a novel and selective SphK2 (sphingosine kinase-2) inhibitor (IC50 = 4.30 μM) with antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 384.92 |
|---|---|
| Molecular Formula | C18H25ClN2O3S |
| CAS No. | 1449240-68-9 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(N(CCN)C/1=O)SC1=C/CCC2=CC=C(OCCCC)C=C2.[H] |
| Synonyms | K145; K-145; K 145; K145 HCl; K145 hydrochloride |
| Protocol | In Vitro | K145 (0-10 µM; 24-72 hours; U937 cells) treatment significantly inhibits the growth of U937 cells in a concentration-dependent manner. K145 (4-8 µM; 3 hours; U937 cells) treatment decreases the phosphorylation of ERK and Akt. K145 (10 µM; 24 hours; U937 cells) treatment significantly induces apoptosis in U937 cells. Treatment with K145 (10 µM) causes a decrease of total cellular S1P without significant effects on ceramide levels. |
|---|---|---|
| In Vivo | K145 (50 mg/kg; oral gavage; daily; for 15 days; BALB/c-nu mice) treatment significantly inhibits the growth of U937 tumors in nude mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5979 mL | 12.9897 mL | 25.9794 mL | 51.9588 mL |
| 5mM | 0.5196 mL | 2.5979 mL | 5.1959 mL | 10.3918 mL |
| 10mM | 0.2598 mL | 1.2990 mL | 2.5979 mL | 5.1959 mL |
| 20mM | 0.1299 mL | 0.6495 mL | 1.2990 mL | 2.5979 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.