K03861 (AUZ 454)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1160 | Check With Us |
| 500mg | $1750 | Check With Us |
| 1g | $2625 | Check With Us |
: Cat #: V1536 CAS #: 853299-07-7 Purity ≥ 98%
Description: K03861 (K0 3861; AUZ-454; K-03861; AUZ 454), an aminopyrimidine-phenyl urea analog, is novel and potent type II cyclin-dependent kinase-CDK2 inhibitor with potential anticancer activity.
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| Molecular Weight (MW) | 501.50 |
|---|---|
| Molecular Formula | C24H26F3N7O2 |
| CAS No. | 853299-07-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (199.4 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 15 mg/mL (29.9 mM) | |
| Synonyms | K03861; AUZ454; K-03861; AUZ 454; K 03861; AUZ-454 |
| Protocol | In Vitro | AUZ 454 (K03861) (10-20 μM; 1, 2, 3, and 4 days) has a inhibitory effect on Caki-1 and ACHN cells with WTAP overexpression by CCK8 assays |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9940 mL | 9.9701 mL | 19.9402 mL | 39.8804 mL |
| 5mM | 0.3988 mL | 1.9940 mL | 3.9880 mL | 7.9761 mL |
| 10mM | 0.1994 mL | 0.9970 mL | 1.9940 mL | 3.9880 mL |
| 20mM | 0.0997 mL | 0.4985 mL | 0.9970 mL | 1.9940 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.