K-80003
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1050 | Check With Us |
| 200mg | $1575 | Check With Us |
| 500mg | $2655 | Check With Us |
: Cat #: V33314 CAS #: 1292821-90-9 Purity ≥ 99%
Description: K-80003 (TX-803; K-80003; TX803; K80003) is a novel and potent inhibitor of Akt activation (tRXRα-dependent) with potential anti-cancer activity.
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| Molecular Weight (MW) | 336.40 |
|---|---|
| Molecular Formula | C22H21FO2 |
| CAS No. | 1292821-90-9 |
| SMILES Code | O=C(O)CC(C1=C/2C=CC(F)=C1)=C(C)C2=C\C3=CC=C(C(C)C)C=C3 |
| Synonyms | K-80003; K80003; K 80003 |
| Protocol | In Vitro | When MCF-7 cells are cotreated with K-80003, TNFα-induced colocalization of tRXRα with p85α in the cytoplasm is inhibited, resulting in tRXRα nuclear localization. Western blotting shows that K-80003-stabilized tetrameric form of tRXRα is found exclusively in the nuclear fraction, while tRXRα monomer is distributed both in the nuclear and cytoplasmic fractions. |
|---|---|---|
| In Vivo | K-80003 is a potent inhibitor of AKT activation by all-trans-retinoic acid. K-80003 displays enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity to RXRα but lacks COX inhibitory activity. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9727 mL | 14.8633 mL | 29.7265 mL | 59.4530 mL |
| 5mM | 0.5945 mL | 2.9727 mL | 5.9453 mL | 11.8906 mL |
| 10mM | 0.2973 mL | 1.4863 mL | 2.9727 mL | 5.9453 mL |
| 20mM | 0.1486 mL | 0.7432 mL | 1.4863 mL | 2.9727 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.