JX-06
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $750 | Check With Us |
| 1g | $1250 | Check With Us |
| 5g | $3165 | Check With Us |
: Cat #: V23059 CAS #: 729-46-4 Purity ≥ 99%
Description: JX-06 is a novel and potent pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 324.51 |
|---|---|
| Molecular Formula | C10H16N2O2S4 |
| CAS No. | 729-46-4 |
| SMILES Code | S=C(SSC(N1CCOCC1)=S)N2CCOCC2 |
| Synonyms | JX-06; JX 06; JX06 |
| Protocol | In Vitro | JX06 (1-10 μM; 24 hours) induces ROS generation in cancer cells with high extracellular acidification rate (ECAR)/ oxygen consumption rate (OCR). JX06 (1-10 μM) increases glucose uptake and intracellular ATP level and reduces aerobic glycolysis determined by the lactate production in A549 cells. JX06 (0.1-10 μM; 6-24 hours) inhibits PDHA1 phosphorylation in A549 cells in a time- and dose-dependent manner. JX06 (0-0.6 μM; 72 hours) dose-dependently suppresses the growth of A549 cells. JX06 (1-10 μM; 48 hours) induces cell apoptosis in cancer cells with high ECAR/OCR. JX06 barely shows inhibitory activity against PDK4 at a concentration of 10 μM. |
|---|---|---|
| In Vivo | JX06 (40-80 mg/kg; i.p. for 21 days) inhibits tumor growth in vivo. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0816 mL | 15.4078 mL | 30.8157 mL | 61.6314 mL |
| 5mM | 0.6163 mL | 3.0816 mL | 6.1631 mL | 12.3263 mL |
| 10mM | 0.3082 mL | 1.5408 mL | 3.0816 mL | 6.1631 mL |
| 20mM | 0.1541 mL | 0.7704 mL | 1.5408 mL | 3.0816 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.