(-)-JQ-1 | CAS 1268524-71-5

(-)-JQ-1

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$750	Check With Us
500mg	$1250	Check With Us
1g	$1875	Check With Us

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Cat #: V3676 CAS #: 1268524-71-5 Purity ≥ 98%

Description: (-)-JQ-1 is the (R)-Enantiomer of JQ1 or the stereoisomer of (+)-JQ1.

References: Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	456.99
Molecular Formula	C23H25ClN4O2S
CAS No.	1268524-71-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 91 mg/mL (199.1 mM)r
	Water: <1 mg/mLr
	Ethanol: 91 mg/mL (199.1 mM)
Solubility In Vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 5 mg/mL
SMILES Code	O=C(C[C@H]1N=C(C2=C(N3C1=NN=C3C)SC(C)=C2C)C4=CC=C(C=C4)Cl)OC(C)(C)C
Synonyms	Bromodomain Inhibitor; (-)-JQ-1; (1)-JQ1; (1)-JQ 1; (R)-(-)-JQ1 Enantiomer

Protocol	In Vitro	(R)-(-)-JQ1 Enantiomer shows no significant interaction with any bromodomain. Besides, (R)-(-)-JQ1 Enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC).

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1882 mL	10.9412 mL	21.8823 mL	43.7646 mL
5mM	0.4376 mL	2.1882 mL	4.3765 mL	8.7529 mL
10mM	0.2188 mL	1.0941 mL	2.1882 mL	4.3765 mL
20mM	0.1094 mL	0.5471 mL	1.0941 mL	2.1882 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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