JNK Inhibitor VIII (TCS JNK 6o)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1350 | Check With Us |
| 250mg | $2550 | Check With Us |
| 500mg | $3825 | Check With Us |
: Cat #: V28892 CAS #: 894804-07-0 Purity ≥ 99%
Description: JNK Inhibitor VIII (TCS JNK 6o) is a selective and ATP-competitive inhibitor of c-Jun N-terminal kinases (JNK-1, -2, and -3) with Kis of 2 nM, 4 nM, 52 nM, respectively, and has IC50 of 45 nM and 160 nM for JNK-1 and -2, respectively.
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| Molecular Weight (MW) | 356.38 |
|---|---|
| Molecular Formula | C18H20N4O4 |
| CAS No. | 894804-07-0 |
| SMILES Code | O=C(NC1=NC(OCC)=C(C#N)C(N)=C1)CC2=CC(OC)=CC=C2OC |
| Synonyms | TCS-JNK-6o; TCS JNK-6o; TCS-JNK 6o; c-Jun N-terminal Kinase Inhibitor VIII; JNK Inhibitor VIII |
| Protocol | In Vitro | JNK Inhibitor VIII (TCS JNK 6o) shows over 1000- fold selective for JNK-1 and -2 over other MAP kinases including ERK2, p38α, and p38δ. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8060 mL | 14.0300 mL | 28.0599 mL | 56.1199 mL |
| 5mM | 0.5612 mL | 2.8060 mL | 5.6120 mL | 11.2240 mL |
| 10mM | 0.2806 mL | 1.4030 mL | 2.8060 mL | 5.6120 mL |
| 20mM | 0.1403 mL | 0.7015 mL | 1.4030 mL | 2.8060 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.