JNJ-31020028 | CAS 1094873-14-9

JNJ-31020028

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$750	In Stock
250mg	$1300	In Stock
500mg	$1950	In Stock

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Cat #: V2943 CAS #: 1094873-14-9 Purity ≥ 98%

Description: JNJ-31020028 (JNJ31020028) is a potent, high-affinitiy, selective and brain penetrant small molecule antagonist of the neuropeptide Y(2) receptor with pIC50=8.07 (human); pIC50=8.22 (rat); it is >100-fold selective versus human Y1/Y4/Y5 receptors.

References: Shoblock JR, et al. In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	565.68
Molecular Formula	C34H36FN5O2
CAS No.	1094873-14-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: >20 mg/mLr
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	JNJ 31020028; JNJ31020028; JNJ-31020028; Chemical Name: N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide Exact Mass: 565.2853

Protocol	In Vitro	JNJ-31020028 (0-10 μM) selectively binds with hY2 , rY2 and mY2 with pIC50 values of 8.07, 8.22 and 8.21, respectively
	In Vivo	JNJ-31020028 (0-20 mg/kg; s.c. once) affects the level of plasma corticosterone and refeeding result in stressed animals
	Animal model	Stressed and nonstressed male Sprague-Dawley rats
	Dosages	0, 3, 10 and 20 mg/kg
	Administration	Subcutaneous injection; 0-20 mg/kg once

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7678 mL	8.8389 mL	17.6778 mL	35.3557 mL
5mM	0.3536 mL	1.7678 mL	3.5356 mL	7.0711 mL
10mM	0.1768 mL	0.8839 mL	1.7678 mL	3.5356 mL
20mM	0.0884 mL	0.4419 mL	0.8839 mL	1.7678 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.