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| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | 3-6 Days |
| 10mg | $120 | 3-6 Days |
| 25mg | $190 | 3-6 Days |
| 50mg | $300 | 3-6 Days |
| 100mg | $410 | 3-6 Days |
| 250mg | $610 | 3-6 Days |
| 500mg | $860 | 3-6 Days |
: Cat #: V4502 CAS #: 821768-06-3 Purity ≥ 99%
Description: JNJ-17203212 is a novel, potent, reversible, competitive and selective TRPV1 antagonist with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. JNJ-17203212 inhibits capsaicin- and H+-induced channel activation (pIC50 values are 6.32 and 7.23 respectively) and exhibits antitussive and analgesic activity in vivo. JNJ-17203212, reduces sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. These data indicate that TRPV1 is involved in the pathogenesis of visceral hypersensitivity and that JNJ-17203212 may be a potential therapeutic agent for functional bowel disorders characterized by abdominal hypersensitivity, such as irritable bowel syndrome.
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| Molecular Weight (MW) | 419.324323892593 |
|---|---|
| Molecular Formula | C17H15F6N5O |
| CAS No. | 821768-06-3 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | JNJ-17203212; JNJ 17203212; JNJ17203212. |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3848 mL | 11.9239 mL | 23.8479 mL | 47.6958 mL |
| 5mM | 0.4770 mL | 2.3848 mL | 4.7696 mL | 9.5392 mL |
| 10mM | 0.2385 mL | 1.1924 mL | 2.3848 mL | 4.7696 mL |
| 20mM | 0.1192 mL | 0.5962 mL | 1.1924 mL | 2.3848 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.