Ixazomib citrate (MLN 9708; Ninlaro)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$445	Check With Us
1g	$595	Check With Us
5g	$1505	Check With Us

: [email protected] [email protected]

Cat #: V0687 CAS #: 1201902-80-8 Purity ≥ 98%

Description: MLN9708 (also known as ixazomib citrate; MLN-9708; trade name Ninlaro), the citrate salt of Ixazomib (MMLN2238; MMLN-2238), is a prodrug of Ixazomib (MMLN-2238) which is an orally bioavailable and 2nd generation proteasome inhibitor (PI) with potential antineoplastic activity.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	517.12
Molecular Formula	C20H23BCl2N2O9
CAS No.	1201902-80-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (193.4 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	0.5% hydroxyethyl cellulose: 30 mg/mL
SMILES Code	O=C(C(C1)(CC(O)=O)OB([C@@H](NC(CNC(C2=CC(Cl)=CC=C2Cl)=O)=O)CC(C)C)OC1=O)O
Synonyms	MLN9708; MLN-9708; MLN 9708; ixazomib citrate; MMLN-2238-prodrug; MMLN 2238-prodrug; MMLN2238-prodrug; Ixazomib-prodrug; Ninlaro

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9338 mL	9.6689 mL	19.3379 mL	38.6757 mL
5mM	0.3868 mL	1.9338 mL	3.8676 mL	7.7351 mL
10mM	0.1934 mL	0.9669 mL	1.9338 mL	3.8676 mL
20mM	0.0967 mL	0.4834 mL	0.9669 mL	1.9338 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.