Itraconazole
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $700 | Check With Us |
| 10g | $1150 | Check With Us |
| 20g | $1725 | Check With Us |
: Cat #: V0805 CAS #: 84625-61-6 Purity ≥ 98%
Description: Itraconazole (Orungal, Oriconazole, Sporanox, R51211; R-51211), a marketed triazole-based antifungal drug since 1984, is a potent inhibitor of CYP3A4 that has been widely used for the treatment of fungal infections.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 705.65 |
|---|---|
| Molecular Formula | C35H38Cl2N8O4 |
| CAS No. | 84625-61-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 7 mg/mL (9.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 5% DMSO+70% PEG 300+ddH2O: 9mg/mL |
| SMILES Code | O=C1N(C(CC)C)N=CN1C2=CC=C(N3CCN(C4=CC=C(OC[C@@H]5O[C@@](CN6N=CN=C6)(C7=CC=C(Cl)C=C7Cl)OC5)C=C4)CC3)C=C2 |
| Synonyms | R51211, Orungal, Oriconazole, Sporanox, R 51211; R-51211, Itraconazole, Itraconazolum, Itraconazol, Itrizole |
| Protocol | In Vitro | Itraconazole inhibits endothelial cell cycle progression at the G1 phase in vitro. |
|---|---|---|
| In Vivo | Itraconazole (75-100 mg/kg; oral gavage; twice per day; for 18 days; female outbred athymic nude mice) treatment suppresses Hh pathway activity and the growth of medulloblastoma in a mouse allograft model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.4171 mL | 7.0857 mL | 14.1713 mL | 28.3427 mL |
| 5mM | 0.2834 mL | 1.4171 mL | 2.8343 mL | 5.6685 mL |
| 10mM | 0.1417 mL | 0.7086 mL | 1.4171 mL | 2.8343 mL |
| 20mM | 0.0709 mL | 0.3543 mL | 0.7086 mL | 1.4171 mL |
| Quality Control Documentation |
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|---|
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.