Itanapraced

This product is for research use only, not for human use. We do not sell to patients.

Itanapraced
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$90To Be Confirmed
10mg$130To Be Confirmed
50mg$400To Be Confirmed
100mg$590To Be Confirmed

Cat #: V22768 CAS #: 749269-83-8 Purity ≥ 99%

Description: Itanapraced (CHF5074) is an orally bioactive gamma-secretase modulator and a nonsteroidal anti~inflammatory analogue. Itanapraced can reduce the secretion of Aβ42 and Aβ40 with IC50s of 3.6 and 18.4 μM respectively. Itanapraced inhibits oxygen glucose deprivation (OGD)-induced apoptosis in hippocampal neurons. Itanapraced may be used in Alzheimer's disease (AD) research.

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Molecular Weight (MW)325.1604
Molecular FormulaC16H11Cl2FO2
CAS No.749269-83-8
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsCHF 5074; CHF-5074; CHF5074
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0754 mL15.3770 mL30.7541 mL61.5081 mL
5mM0.6151 mL3.0754 mL6.1508 mL12.3016 mL
10mM0.3075 mL1.5377 mL3.0754 mL6.1508 mL
20mM0.1538 mL0.7689 mL1.5377 mL3.0754 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.