IRX5183 (NRX195183, VTP195183, AGN195183)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2050 | Check With Us |
| 200mg | $3075 | Check With Us |
| 500mg | $5190 | Check With Us |
: Cat #: V22666 CAS #: 367273-07-2 Purity ≥ 99%
Description: IRX5183 (NRX-195183, VTP-195183, AGN-195183) is a potent, selective, and orally bioavailable retinoid acid receptor (RAR) alpha agonist with potential antineoplastic activity.
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| Molecular Weight (MW) | 437.86 |
|---|---|
| Molecular Formula | C22H22ClF2NO4 |
| CAS No. | 367273-07-2 |
| SMILES Code | O=C(O)C1=C(F)C=C(NC(C2=C(O)C(Cl)=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F |
| Synonyms | AGN-195183; AGN195183; AGN195183; IRX5183; IRX-5183; IRX 5183; NRX195183; NRX-195183; NRX 195183; VTP-195183; VTP195183; VTP 195183; |
| Protocol | In Vitro | AGN-195183 (IRX-5183; Compound 4) inhibits the growth of breast cancer cell lines, and is inactive in an in vivo model of topical irritation. AGN-195183 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3. AGN-195183 does not cause the topical irritation induced by the RARa-selective retinoid, Am-580. AGN-195183 is currently in Phase I/IIA clinical trials in cancer patients. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2838 mL | 11.4192 mL | 22.8384 mL | 45.6767 mL |
| 5mM | 0.4568 mL | 2.2838 mL | 4.5677 mL | 9.1353 mL |
| 10mM | 0.2284 mL | 1.1419 mL | 2.2838 mL | 4.5677 mL |
| 20mM | 0.1142 mL | 0.5710 mL | 1.1419 mL | 2.2838 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.