Irbesartan HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $650 | Check With Us |
| 10g | $950 | Check With Us |
| 20g | $1425 | Check With Us |
: Cat #: V15311 CAS #: 329055-23-4 Purity ≥ 98%
Description: Irbesartan HCl (formerly known as SR-47436 and BMS-186295) is a novel, highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 464.99 |
|---|---|
| Molecular Formula | C25H29ClN6O |
| CAS No. | 329055-23-4 |
| Protocol | In Vitro | Irbesartan hydrochloride (20 μM, 3 h) reduces Th22 cells chemotaxis in vitro |
|---|---|---|
| In Vivo | Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) reduces Th22 lymphocytosis and serum IL-22 level in Ang II-infused mice | |
| Animal model | C57BL/6 mice | |
| Dosages | 50 mg/kg | |
| Administration | oral gavage; 50 mg/kg/d; once daily |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1506 mL | 10.7529 mL | 21.5058 mL | 43.0117 mL |
| 5mM | 0.4301 mL | 2.1506 mL | 4.3012 mL | 8.6023 mL |
| 10mM | 0.2151 mL | 1.0753 mL | 2.1506 mL | 4.3012 mL |
| 20mM | 0.1075 mL | 0.5376 mL | 1.0753 mL | 2.1506 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.