IRAK inhibitor 1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1350 | To Be Confirmed |
| 250mg | $1999 | To Be Confirmed |
| 500mg | $2995 | To Be Confirmed |
: Cat #: V34066 CAS #: 1042224-63-4 Purity ≥ 99%
Description: IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.
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| Molecular Weight (MW) | 293.37 |
|---|---|
| Molecular Formula | C17H19N5 |
| CAS No. | 1042224-63-4 |
| SMILES Code | C1(NC2CCNCC2)=NC(C3=CN=C4C=CC=CN43)=CC=C1 |
| Synonyms | IRAK4-IN-1; IRAK Inhibitor 1 |
| Protocol | In Vitro | IRAK inhibitor 1 possesses significant potency in an IRAK-4 enzyme assay but is poorly active against JNK-1 and JNK-2. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4087 mL | 17.0433 mL | 34.0866 mL | 68.1733 mL |
| 5mM | 0.6817 mL | 3.4087 mL | 6.8173 mL | 13.6347 mL |
| 10mM | 0.3409 mL | 1.7043 mL | 3.4087 mL | 6.8173 mL |
| 20mM | 0.1704 mL | 0.8522 mL | 1.7043 mL | 3.4087 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.