IRAK-1/4 Inhibitor
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1080 | Check With Us |
| 500mg | $1836 | Check With Us |
| 1g | $2754 | Check With Us |
: Cat #: V22652 CAS #: 509093-47-4 Purity ≥ 99%
Description: IRAK-1/4 Inhibitor is a novel inhibitor of interleukin-1 receptor-associated kinase (IRAK)-1/4.
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| Molecular Weight (MW) | 395.41 |
|---|---|
| Molecular Formula | C20H21N5O4 |
| CAS No. | 509093-47-4 |
| SMILES Code | O=C(NC1=NC2=CC=CC=C2N1CCN3CCOCC3)C4=CC=CC([N+]([O-])=O)=C4 |
| Synonyms | IRAK-1/4 Inhibitor |
| Protocol | In Vitro | RAK-1-4 Inhibitor I has IC50 greater than the highest concentration tested (10 μM) against a panel of 27 other kinases, including the most closely homologous (outside of the IRAK family) Lck and pp60SRC. Additionally, IRAK-1-4 Inhibitor I does not show any signs of cytotoxicity in a 72 h proliferation assay in HeLa cells (ED50>30 μM). Significant inhibition of IRAK-1 is observed with IRAK-1-4 Inhibitor I (IRAK-1 IC50=0.3 μM). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5290 mL | 12.6451 mL | 25.2902 mL | 50.5804 mL |
| 5mM | 0.5058 mL | 2.5290 mL | 5.0580 mL | 10.1161 mL |
| 10mM | 0.2529 mL | 1.2645 mL | 2.5290 mL | 5.0580 mL |
| 20mM | 0.1265 mL | 0.6323 mL | 1.2645 mL | 2.5290 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.