Ipratropium Bromide (Sch 1000)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $290 | Check With Us |
| 2g | $520 | Check With Us |
| 5g | $800 | Check With Us |
: Cat #: V1178 CAS #: 22254-24-6 Purity ≥ 98%
Description: Ipratropium Bromide (Sch 1000; Sch1000; Atrovent, Apovent, Ipraxa, Rinatec) is a potent antagonist of M3 type muscarinic acetylcholine receptors that opens up the medium and large airways in the lungs.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 412.37 |
|---|---|
| Molecular Formula | C20H30BrNO3 |
| CAS No. | 22254-24-6 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 83 mg/mL (201.3 mM)rr |
| Water: 83 mg/mL (201.3 mM)rr | |
| Ethanol: 83 mg/mL (201.3 mM) | |
| SMILES Code | O=C(OC1C[C@]([N+]2(C)C(C)C)([H])CC[C@]2([H])C1)C(C3=CC=CC=C3)CO.[Br-] |
| Synonyms | Sch-1000; ipratropium bromide, Sch 1000; Sch1000; trade names: Atrovent, Apovent, Ipraxa, Rinatec |
| Protocol | In Vivo | Ipratropium bromide (1.0 μg/kg； Intravenous injection; Single dose) Enhances bronchoconstriction caused by vagus nerve stimulation |
|---|---|---|
| Animal model | Guinea-pigs of the Dunkin Hartley strain | |
| Dosages | 0.1-1 μg/kg | |
| Administration | Intravenous injection; single dose |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4250 mL | 12.1250 mL | 24.2501 mL | 48.5001 mL |
| 5mM | 0.4850 mL | 2.4250 mL | 4.8500 mL | 9.7000 mL |
| 10mM | 0.2425 mL | 1.2125 mL | 2.4250 mL | 4.8500 mL |
| 20mM | 0.1213 mL | 0.6063 mL | 1.2125 mL | 2.4250 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.