IPN-60090 ( IACS-6274)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$3600	Check With Us
200mg	$5400	Check With Us
500mg	$9110	Check With Us

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Cat #: V40795 CAS #: 1853164-83-6 Purity ≥ 98%

Description: IPN-60090 ( IACS-6274; IPN60090) is a novel, potent, orally bioavailable and specific inhibitor of GLS1 (the kidney-type glutaminase), which is an important enzyme for metabolic energy production.

References: Maria Emilia Di Francesco, et al. Gls1 inhibitors for treating disease. WO2016004404A2.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	532.52
Molecular Formula	C24H27F3N8O3
CAS No.	1853164-83-6
SMILES Code	O=C(NC)C1=CN(C[C@H](F)CCC2=CC=C(NC(CC3=CC(OC4CC(F)(F)C4)=CC(C)=N3)=O)N=N2)N=N1
Synonyms	IPN-60090; IACS6274; IPN 60090; IACS-6274; IPN60090; IACS 6274;

Protocol	In Vitro	There are two known isoforms of glutaminase: GLS-1 (also called kidney-type or KGA), and GLS-2 (also called liver-type or LGA). GLS-1 is ubiquitous and GLS-2 expression appears limited primarily to the liver.
Protocol	In Vivo	IPN60090 (3 mg/kg for i.v.; 10 mg/kg for p.o.) has excellent pharmacokinetic properties, with CL=4.1 mL/min/kg, t1/2=1 hour, Cmax=19 μM, F%=89%.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8779 mL	9.3893 mL	18.7786 mL	37.5573 mL
5mM	0.3756 mL	1.8779 mL	3.7557 mL	7.5115 mL
10mM	0.1878 mL	0.9389 mL	1.8779 mL	3.7557 mL
20mM	0.0939 mL	0.4695 mL	0.9389 mL	1.8779 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.