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Ipatasertib HCl (GDC0068)

This product is for research use only, not for human use. We do not sell to patients.

Ipatasertib HCl (GDC0068)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
10mg$100To Be Confirmed
25mg$150To Be Confirmed
50mg$250To Be Confirmed
100mg$450To Be Confirmed
250mg$750To Be Confirmed
500mg$1350To Be Confirmed
email: [email protected]        [email protected]

Cat #: V22634 CAS #: 1489263-16-2 Purity ≥ 99%

Description: Ipatasertib hydrochloride (GDC-0068) is a novel, potent, orally bioavailable, ATP-competitive and highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, it showed 620-fold selectivity over PKA. GDC-0068 is used for the treatment of human cancers. The PI3K-AKT pathway regulates cell growth, survival and tumorigenesis. GDC-0068 binds to and blocks the activation of AKT, which result in cell cycle arrest, inhibition of tumor cell proliferation and induction of tumor cell death. PI3K-AKT is pathway frequently activated in tumors, thus tumors with PTEN or PI3K mutations, which lead to activation of AKT are with high sensitivity to GDC-0068.

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Molecular FormulaC24H33Cl2N5O2
CAS No.1489263-16-2
SMILES CodeO=C(N1CCN(C2=C([C@H](C)C[C@H]3O)C3=NC=N2)CC1)[C@@H](C4=CC=C(Cl)C=C4)CNC(C)C.[H]Cl           
SynonymsGDC0068; GDC-0068; GDC 0068; RG7440; RG-7440; RG 7440
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.