Iodopravadoline (AM630)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $780 | Check With Us |
| 500mg | $1250 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V22612 CAS #: 164178-33-0 Purity ≥ 99%
Description: Iodopravadoline, formerly known as AM630, is an inverse agonist at the human cannabinoid CB1 receptor.
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- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 504.3685 |
|---|---|
| Molecular Formula | C23H25IN2O3 |
| CAS No. | 164178-33-0 |
| Protocol | In Vitro | The next objective was to probe for differences in the the GBM-derived cell lines by looking at the expression changes driven by the CB2 receptor inverse agonist AM630. This study found that AM630 drove a substantial transcriptional response in the core cell population. |
|---|---|---|
| In Vivo | WIN-induced inhibition of CAP responses in sensory neurons was reversed by AM630 pre-treatment and AM251 co-treatment (25 μM each), as these conditions inhibit WIN responses. Hindpaw injections of AM630 and AM251 did not produce nocifensive behaviors. However, both compounds modulated CAP-induced thermal hyperalgesia in wild-type mice and rats, but not TRPA1 null-mutant mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9827 mL | 9.9134 mL | 19.8268 mL | 39.6535 mL |
| 5mM | 0.3965 mL | 1.9827 mL | 3.9654 mL | 7.9307 mL |
| 10mM | 0.1983 mL | 0.9913 mL | 1.9827 mL | 3.9654 mL |
| 20mM | 0.0991 mL | 0.4957 mL | 0.9913 mL | 1.9827 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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Concentration(final)
C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.