INVIVO74978
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1100 | Check With Us |
| 500mg | $1800 | Check With Us |
| 1g | $2700 | Check With Us |
: Cat #: V25190 CAS #: 778274-97-8 Purity ≥ 99%
Description: INVIVO74978 is a novel and potent Multi-kinase inhibitor.
References: Qiang Ding, et al. Novel compounds and compositions as protein kinase inhibitors. WO2004089286A2.
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| Molecular Weight (MW) | 418.37 |
|---|---|
| Molecular Formula | C20H17F3N4O3 |
| CAS No. | 778274-97-8 |
| SMILES Code | O=C(NCCO)C1=CC=C(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)C=C1 |
| Synonyms | MDK74978; MDK-74978; MDK 74978. Multi-kinase inhibitor I |
| Protocol | In Vitro | Multi-kinase inhibitor 1 (compound 68) is a potent multi-kinase inhibitor. The protein kinases represent a large family of proteins, which play a central role in the regulation of a wide variety of cellular processes and maintaining control over cellular function. These kinases include receptor tyrosine kinases, such as platelet derived growth factor receptor kinase(PDGF-R), the receptor kinase for stem cell factor, c-Kit, and non-receptor tyrosine kinases, such as the fusion kinase Bcr-abl. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3902 mL | 11.9511 mL | 23.9023 mL | 47.8046 mL |
| 5mM | 0.4780 mL | 2.3902 mL | 4.7805 mL | 9.5609 mL |
| 10mM | 0.2390 mL | 1.1951 mL | 2.3902 mL | 4.7805 mL |
| 20mM | 0.1195 mL | 0.5976 mL | 1.1951 mL | 2.3902 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.