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INCB086550

This product is for research use only, not for human use. We do not sell to patients.

INCB086550
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$4500To Be Confirmed
200mg$6750To Be Confirmed
500mg$11390To Be Confirmed
email: [email protected]        [email protected]

Cat #: V4418 CAS #: 2230911-59-6 Purity ≥ 99%

Description: INCB-086550 (INCB-086550) is a novel, investigational and selective small molecule PD-1/PD-L1 inhibitor based on the biphenyl scaffold core structure first disclosed by BMS company.

References: WU LIANGXING, et al. BENZOOXAZOLE DERIVATIVES AS IMMUNOMODULATORS. WO2018119266A1.

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Molecular Weight (MW)693.79
Molecular FormulaC41H39N7O4
CAS No.2230911-59-6
SMILES Code CC1=C(C=CC=C1C2=NC3=CC(=CC(=C3O2)C#N)CN4CCC(C4)C(=O)O)C5=C(C(=CC=C5)NC6=NC=CC7=CC(=CN=C76)CN8CCC(C8)O)C
SynonymsINCB 86550; PD-1; PD-L1-IN-8; INCB086550; INCB-086550; INCB 086550; INCB86550; INCB-86550;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.4414 mL7.2068 mL14.4136 mL28.8272 mL
5mM0.2883 mL1.4414 mL2.8827 mL5.7654 mL
10mM0.1441 mL0.7207 mL1.4414 mL2.8827 mL
20mM0.0721 mL0.3603 mL0.7207 mL1.4414 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.