Ilaprazole (IY-81149)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50mg	$750	Check With Us
100mg	$1125	Check With Us
200mg	$1685	Check With Us

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Cat #: V22465 CAS #: 172152-36-2 Purity ≥ 98%

Description: Ilaprazole (IY81149) is an orally bioavailable anti-ulcer agent, acting as a proton pump inhibitor (PPI) and is used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer.

References: Kwon D, et al. Effects of IY-81149, a newly developed proton pump inhibitor, on gastric acid secretion in vitro and in vivo. Arzneimittelforschung. 2001;51(3):204-13.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	366.44
Molecular Formula	C19H18N4O2S
CAS No.	172152-36-2
SMILES Code	O=S(C1=NC2=CC(N3C=CC=C3)=CC=C2N1)CC4=NC=CC(OC)=C4C

Protocol	In Vitro	On cumulation of 14C-aminopyrine in histamine stimulated parietal cells, the IC50 of Ilaprazole (IY-81149) sodium is 9 nM
Protocol	In Vivo	Ilaprazole (3-30 mg/kg; i.d.) dose-dependently inhibits gastric acid secretion

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.7290 mL	13.6448 mL	27.2896 mL	54.5792 mL
5mM	0.5458 mL	2.7290 mL	5.4579 mL	10.9158 mL
10mM	0.2729 mL	1.3645 mL	2.7290 mL	5.4579 mL
20mM	0.1364 mL	0.6822 mL	1.3645 mL	2.7290 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.