Ibiglustat L-Malic acid
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $750 | To Be Confirmed |
| 250mg | $1350 | To Be Confirmed |
| 500mg | $2025 | To Be Confirmed |
: Cat #: V32453 CAS #: 1629063-78-0 Purity ≥ 99%
Description: Ibiglustat L-Malic acid (Venglustat; GZ402671; Genz-682452; GZ-452; SAR-402671) is a novel and potent inhibitor of glucosylceramide synthase (GCS) and also a ceramide glucosyltransferase inhibitor.
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| Molecular Weight (MW) | 523.57 |
|---|---|
| Molecular Formula | C₂₄H₃₀FN₃O₇S |
| CAS No. | 1629063-78-0 |
| Synonyms | SAR402671 (L-Malic acid); GZ402671 (L-Malic acid |
| Protocol | In Vitro | Ibiglustat (SAR402671) (1 μM, 15 days) L-Malic acid treated Fabry disease (FD) cells are close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat L-Malic acid can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9100 mL | 9.5498 mL | 19.0996 mL | 38.1993 mL |
| 5mM | 0.3820 mL | 1.9100 mL | 3.8199 mL | 7.6399 mL |
| 10mM | 0.1910 mL | 0.9550 mL | 1.9100 mL | 3.8199 mL |
| 20mM | 0.0955 mL | 0.4775 mL | 0.9550 mL | 1.9100 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.